K(+ )channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport

BACKGROUND: Lung epithelial Na(+ )channels (ENaC) are regulated by cell Ca(2+ )signal, which may contribute to calcium antagonist-induced noncardiogenic lung edema. Although K(+ )channel modulators regulate ENaC activity in normal lungs, the therapeutical relevance and the underlying mechanisms have...

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Détails bibliographiques
Auteurs principaux: Han, Dong-Yun, Nie, Hong-Guang, Gu, Xiu, Nayak, Ramesh C, Su, Xue-Feng, Fu, Jian, Chang, Yongchang, Rao, Vijay, Ji, Hong-Long
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2010
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889873/
https://ncbi.nlm.nih.gov/pubmed/20507598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-11-65
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