Efficient Generation of Germ Line Transmitting Chimeras from C57BL/6N ES Cells by Aggregation with Outbred Host Embryos

Genetically modified mouse strains derived from embryonic stem (ES) cells have become essential tools for functional genomics and biomedical research. Large scale mutagenesis projects are producing libraries of mutant C57BL/6 (B6) ES cells to enable the functional annotation of every gene of the mou...

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Detalhes bibliográficos
Main Authors: Gertsenstein, Marina, Nutter, Lauryl M. J., Reid, Tammy, Pereira, Monica, Stanford, William L., Rossant, Janet, Nagy, Andras
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889837/
https://ncbi.nlm.nih.gov/pubmed/20582321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011260
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