Spectrum of HNF1A Somatic Mutations in Hepatocellular Adenoma Differs From That in Patients With MODY3 and Suggests Genotoxic Damage

OBJECTIVE: Maturity onset diabetes of the young type 3 (MODY3) is a consequence of heterozygous germline mutation in HNF1A. A subtype of hepatocellular adenoma (HCA) is also caused by biallelic somatic HNF1A mutations (H-HCA), and rare HCA may be related to MODY3. To better understand a relationship...

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Detalhes bibliográficos
Main Authors: Jeannot, Emmanuelle, Mellottee, Lucille, Bioulac-Sage, Paulette, Balabaud, Charles, Scoazec, Jean-Yves, Tran Van Nhieu, Jeanne, Bacq, Yannick, Michalak, Sophie, Buob, David, Laurent-Puig, Pierre, Rusyn, Ivan, Zucman-Rossi, Jessica
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2010
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889786/
https://ncbi.nlm.nih.gov/pubmed/20393147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1819
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