Detrimental Effect of the Proteasome Inhibitor, Bortezomib in Bacterial Superantigen- and Lipopolysaccharide-induced Systemic Inflammation

Bacterial superantigen (BSAg)–induced toxic shock syndrome (TSS) and bacterial lipopolysaccharide (LPS)–induced shock are characterized by severe systemic inflammation. As nuclear factor κB (NFκB) plays an important role in inflammation and bortezomib, a proteasome inhibitor widely used in cancer ch...

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Main Authors: Tilahun, Ashenafi Y, Theuer, Jayne E, Patel, Robin, David, Chella S, Rajagopalan, Govindarajan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889741/
https://ncbi.nlm.nih.gov/pubmed/20372109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.53
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