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Detrimental Effect of the Proteasome Inhibitor, Bortezomib in Bacterial Superantigen- and Lipopolysaccharide-induced Systemic Inflammation

Bacterial superantigen (BSAg)–induced toxic shock syndrome (TSS) and bacterial lipopolysaccharide (LPS)–induced shock are characterized by severe systemic inflammation. As nuclear factor κB (NFκB) plays an important role in inflammation and bortezomib, a proteasome inhibitor widely used in cancer ch...

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Main Authors: Tilahun, Ashenafi Y, Theuer, Jayne E, Patel, Robin, David, Chella S, Rajagopalan, Govindarajan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889741/
https://ncbi.nlm.nih.gov/pubmed/20372109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.53
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