Production of guanidine-resistant and -dependent poliovirus mutants from cloned cDNA: mutations in polypeptide 2C are directly responsible for altered guanidine sensitivity.

cDNA fragments representing the region in polypeptide 2C containing mutations in a guanidine-resistant or -dependent mutant were cloned into the wild-type background of an infectious clone. Transfection of COS-1 cells with these plasmids yielded viruses that were either completely resistant to 2.0 m...

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Bibliographische Detailangaben
Hauptverfasser: Pincus, S E, Wimmer, E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1986
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC288960/
https://ncbi.nlm.nih.gov/pubmed/3022012
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