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Metabolic activation of 9([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human lymphoblastoid cell lines infected with Epstein-Barr virus.

9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) is more potent and has a more prolonged inhibitory effect against Epstein-Barr virus (EBV) in vitro than does acyclovir (ACV). To assess the mechanism of this difference, we first compared the extent of phosphorylation of the two drugs...

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Udgivet i:J Virol
Principais autores: Lin, J C, Nelson, D J, Lambe, C U, Choi, E I
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288927/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3021990/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.60.2.569-573.1986
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