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Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation

Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a Parkinson disease-associated, putative cysteine protease found abundantly and selectively expressed in neurons. The crystal structure of apo UCHL1 showed that the active-site residues are not aligned in a canonical form, with the nucleophilic cyst...

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Autors principals: Boudreaux, David A., Maiti, Tushar K., Davies, Christopher W., Das, Chittaranjan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889082/
https://ncbi.nlm.nih.gov/pubmed/20439756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0910870107
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