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Nanog Variability and Pluripotency Regulation of Embryonic Stem Cells - Insights from a Mathematical Model Analysis

The expression of the transcription factors Oct4, Sox2, and Nanog is commonly associated with pluripotency of mouse embryonic stem (ES) cells. However, recent observations suggest that ES cell populations are heterogeneous with respect to the expression of Nanog and that individual ES cells reversib...

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Detalhes bibliográficos
Main Authors: Glauche, Ingmar, Herberg, Maria, Roeder, Ingo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888652/
https://ncbi.nlm.nih.gov/pubmed/20574542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011238
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