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Enhanced Delivery of Erythropoietin Across the Blood-Brain Barrier for Neuroprotection against Ischemic Neuronal Injury

Due to limited penetration of the BBB, many therapeutic agents in clinical use require higher doses in order to reach effective concentrations in brain. In some instances, these high doses elicit severe side effects. In the case of erythropoietin (EPO), an established neuroprotectant against ischemi...

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Autors principals: Zhang, Feng, Xing, Juan, Liou, Anthony Kian-Fong, Wang, Suping, Gan, Yu, Luo, Yumin, Ji, Xuming, Stetler, R. Anne, Chen, Jun, Cao, Guodong
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888513/
https://ncbi.nlm.nih.gov/pubmed/20577577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12975-010-0019-3
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