Fluorine-18-Labeled Fluoromisonidazole Positron Emission and Computed Tomography-Guided Intensity-Modulated Radiotherapy for Head and Neck Cancer: A Feasibility Study

PURPOSE: Hypoxia renders tumor cells radioresistant, limiting locoregional control from radiotherapy (RT). Intensity-modulated RT (IMRT) allows for targeting of the gross tumor volume (GTV) and can potentially deliver a greater dose to hypoxic subvolumes (GTV(h)) while sparing normal tissues. A Mont...

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Hauptverfasser: Lee, Nancy Y., Mechalakos, James G., Nehmeh, Sadek, Lin, Zhixiong, Squire, Olivia D., Cai, Shangde, Chan, Kelvin, Zanzonico, Pasquale B., Greco, Carlo, Ling, Clifton C., Humm, John L., Schöder, Heiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888477/
https://ncbi.nlm.nih.gov/pubmed/17869020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2007.06.039
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