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Discovery and characterization of inhibitors of human palmitoyl acyltransferases

The covalent attachment of palmitate to specific proteins by the action of palmitoyl acyltransferases (PAT) plays critical roles in the biological activities of several oncoproteins. Two PAT activities are expressed by human cells: type 1 PATs that modify the farnesyl-dependent palmitoylation motif...

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Detalhes bibliográficos
Main Authors: Ducker, Charles E., Griffel, Lindsay K., Smith, Ryan A., Keller, Staci N., Zhuang, Yan, Xia, Zuping, Diller, John D., Smith, Charles D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2888271/
https://ncbi.nlm.nih.gov/pubmed/16891450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-06-0114
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