Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts

Mitochondrial DNA (mtDNA) mutations accumulate in a number of ageing tissues and are proposed to play a role in the ageing process. We have previously shown that colonic crypt stem cells accumulate somatic mtDNA point mutations during ageing. These mtDNA mutations result in the loss of the activity...

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Main Authors: Greaves, Laura C., Barron, Martin J., Plusa, Stefan, Kirkwood, Thomas B., Mathers, John C., Taylor, Robert W., Turnbull, Doug M.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Science 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887930/
https://ncbi.nlm.nih.gov/pubmed/20096767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2010.01.013
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