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Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts
Mitochondrial DNA (mtDNA) mutations accumulate in a number of ageing tissues and are proposed to play a role in the ageing process. We have previously shown that colonic crypt stem cells accumulate somatic mtDNA point mutations during ageing. These mtDNA mutations result in the loss of the activity...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Elsevier Science
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2887930/ https://ncbi.nlm.nih.gov/pubmed/20096767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2010.01.013 |
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