Phenyl-α-tert-butyl-nitrone and Benzonidazole Treatment Controlled the Mitochondrial Oxidative Stress and Evolution of Cardiomyopathy in Chronic Chagasic Rats

OBJECTIVES: Determine the pathological importance of oxidative stress-induced injurious processes in chagasic heart dysfunction. BACKGROUND: Trypanosoma cruzi-induced inflammatory pathology and a feedback cycle of mitochondrial dysfunction and oxidative stress may contribute to Chagas disease. METHO...

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Hauptverfasser: Wen, Jian-Jun, Gupta, Shivali, Guan, Zhangjun, Dhiman, Monisha, Condon, David, Lui, Charles, Garg, Nisha Jain
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887697/
https://ncbi.nlm.nih.gov/pubmed/20510218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2010.02.030
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