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Steroid withdrawal in the mouse results in anxiogenic effects of 3α,5β-THP: a possible model of premenstrual dysphoric disorder
RATIONALE: 3α-OH-5α[β]-pregnan-20-one (THP) is a positive modulator of the GABA(A) receptor (GABAR), which underlies its reported anxiolytic effect. However, there are conditions such as premenstrual dysphoric disorder (PMDD) where increases in THP levels can be associated with adverse mood. OBJECTI...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2887339/ https://ncbi.nlm.nih.gov/pubmed/16193334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-005-0168-3 |
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