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Human bone marrow stromal cells display variable anatomic site-dependent response and recovery from irradiation

OBJECTIVES: Orofacial bone is commonly affected by osteoradionecrosis (ORN) during head and neck cancer radiotherapy possibly due to interactions of several factors including radiation damage to resident bone marrow stromal cells (BMSCs). Irradiation causes DNA damage, triggers p53-dependent signali...

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Main Authors: Damek-Poprawa, Monika, Stefanik, Derek, Levin, Lawrence M., Akintoye, Sunday O.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886662/
https://ncbi.nlm.nih.gov/pubmed/20378097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.archoralbio.2010.03.010
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