Genetic ablation of calcium-independent phospholipase A(2)β causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine

Activation of phospholipases leads to the release of arachidonic acid and lysophospholipids that play prominent roles in regulating vasomotor tone. To identify the role of calcium-independent phospholipase A(2)β (iPLA(2)β) in vasomotor function, we measured vascular responses to phenylephrine (PE) a...

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Main Authors: Dietrich, Hans H., Abendschein, Dana R., Moon, Sung Ho, Nayeb-Hashemi, Neema, Mancuso, David J., Jenkins, Christopher M., Kaltenbronn, Kevin M., Blumer, Kendall J., Turk, John, Gross, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886658/
https://ncbi.nlm.nih.gov/pubmed/20382858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00839.2009
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