Regulation of reactive oxygen species by p53: implications for nitric oxide-mediated apoptosis

Nitric oxide (NO) induces vascular smooth muscle cell (VSMC) apoptosis in part through activation of p53. Traditionally, p53 has been thought of as the gatekeeper, determining if a cell should undergo arrest and repair or apoptosis following exposure to DNA-damaging agents, depending on the severity...

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Hauptverfasser: Popowich, Daniel A., Vavra, Ashley K., Walsh, Christopher P., Bhikhapurwala, Hussein A., Rossi, Nicholas B., Jiang, Qun, Aalami, Oliver O., Kibbe, Melina R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2010
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886652/
https://ncbi.nlm.nih.gov/pubmed/20382856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00535.2009
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