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Filaggrin deficient mice exhibit Th17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen
BACKGROUND: Filaggrin is important for skin barrier function and is mutated in 15-20% of patients with atopic dermatitis. OBJECTIVE: To examine whether filaggrin deficiency predisposes to skin inflammation and epicutaneous (EC) sensitization with protein antigen. METHODS: Skin histology in filaggrin...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2886150/ https://ncbi.nlm.nih.gov/pubmed/19665780 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2009.05.042 |
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