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Optimal matrix rigidity for stress fiber polarization in stem cells

The shape and differentiation of human mesenchymal stem cells is especially sensitive to the rigidity of their environment; the physical mechanisms involved are unknown. A theoretical model and experiments demonstrate here that the polarization/alignment of stress-fibers within stem cells is a non-m...

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Bibliographic Details
Main Authors: Zemel, A., Rehfeldt, F., Brown, A. E. X., Discher, D. E., Safran, S. A.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885792/
https://ncbi.nlm.nih.gov/pubmed/20563235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nphys1613
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