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Chronic suppression of mu-opioid receptor signaling in the nucleus accumbens attenuates development of diet-induced obesity in rats

OBJECTIVE: To test the hypothesis that mu-opioid receptor signaling in the nucleus accumbens contributes to hedonic (over)eating and obesity. To investigate the effects of chronic mu-opioid antagonism in the nucleus accumbens core or shell on intake of a palatable diet, and the development of diet-i...

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Detalhes bibliográficos
Main Authors: Lenard, Natalie R., Zheng, Huiyuan, Berthoud, Hans-Rudolf
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885588/
https://ncbi.nlm.nih.gov/pubmed/20065959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ijo.2009.297
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