A new method to detect loss of heterozygosity using cohort heterozygosity comparisons

BACKGROUND: Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor and patient-matched normal DNA samples. However, for many archival sam...

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Hlavní autoři: Green, Michael R, Jardine, Paul, Wood, Peter, Wellwood, Jeremy, Lea, Rod A, Marlton, Paula, Griffiths, Lyn R
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Technical Advance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885361/
https://ncbi.nlm.nih.gov/pubmed/20462409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-195
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