Clinical and Translational Studies of a Phase II Trial of the Novel Oral Akt Inhibitor Perifosine in Relapsed or Relapsed/Refractory Waldenstrom's Macroglobulinemia

BACKGROUND: Waldenstrom's Macroglobulinemia (WM) is a rare low-grade lymphoproliferative disorder. Based on preclinical studies, we conducted a phase II clinical trial testing the efficacy and safety of the Akt inhibitor perifosine in patients with relapsed/refractory WM. PATIENTS AND METHODS:...

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Main Authors: Ghobrial, Irene M., Roccaro, Aldo, Hong, Fangxin, Weller, Edie, Rubin, Nancy, Leduc, Renee, Rourke, Meghan, Chuma, Stacey, Sacco, Antonio, Jia, Xiaoying, Azab, Feda, Azab, Abdel Kareem, Rodig, Scott, Warren, Diane, Harris, Brianna, Varticovski, Lyuba, Sportelli, Peter, Leleu, Xavier, Anderson, Kenneth C., Richardson, Paul G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885252/
https://ncbi.nlm.nih.gov/pubmed/20103671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1837
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