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Dual Binding Mode of the Nascent Polypeptide-associated Complex Reveals a Novel Universal Adapter Site on the Ribosome

Nascent polypeptide-associated complex (NAC) was identified in eukaryotes as the first cytosolic factor that contacts the nascent polypeptide chain emerging from the ribosome. NAC is present as a homodimer in archaea and as a highly conserved heterodimer in eukaryotes. Mutations in NAC cause severe...

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Détails bibliographiques
Auteurs principaux: Pech, Markus, Spreter, Thomas, Beckmann, Roland, Beatrix, Birgitta
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885246/
https://ncbi.nlm.nih.gov/pubmed/20410297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092536
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