Structural Basis of the Lactate-dependent Allosteric Regulation of Oxygen Binding in Arthropod Hemocyanin

Hemocyanin (Hc) is an oxygen carrier protein in which oxygen binding is regulated by allosteric effectors such as H(+) and l-lactate. Isothermal titration calorimetric measurements showed that l-lactate binds to dodecameric and heterohexameric Hc and to the CaeSS3 homohexamer but not to the CaeSS2 m...

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Bibliographic Details
Main Authors: Hirota, Shun, Tanaka, Naoki, Mičetić, Ivan, Di Muro, Paolo, Nagao, Satoshi, Kitagishi, Hiroaki, Kano, Koji, Magliozzo, Richard S., Peisach, Jack, Beltramini, Mariano, Bubacco, Luigi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885213/
https://ncbi.nlm.nih.gov/pubmed/20406810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.076067
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