Structural Basis of the Lactate-dependent Allosteric Regulation of Oxygen Binding in Arthropod Hemocyanin

Hemocyanin (Hc) is an oxygen carrier protein in which oxygen binding is regulated by allosteric effectors such as H(+) and l-lactate. Isothermal titration calorimetric measurements showed that l-lactate binds to dodecameric and heterohexameric Hc and to the CaeSS3 homohexamer but not to the CaeSS2 m...

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Main Authors: Hirota, Shun, Tanaka, Naoki, Mičetić, Ivan, Di Muro, Paolo, Nagao, Satoshi, Kitagishi, Hiroaki, Kano, Koji, Magliozzo, Richard S., Peisach, Jack, Beltramini, Mariano, Bubacco, Luigi
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2010
נושאים:
Protein Structure and Folding
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885213/
https://ncbi.nlm.nih.gov/pubmed/20406810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.076067
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