Mitomycin C Inhibits Ribosomal RNA: A NOVEL CYTOTOXIC MECHANISM FOR BIOREDUCTIVE DRUGS

Mitomycin C (MMC) is a commonly used and extensively studied chemotherapeutic agent requiring biological reduction for activity. Damage to nuclear DNA is thought to be its primary mechanism of cell death. Due to a lack of evidence for significant MMC activation in the nucleus and for in vivo studies...

Full description

Saved in:
Bibliographic Details
Main Authors: Snodgrass, Ryan G., Collier, Abby C., Coon, Amy E., Pritsos, Chris A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885185/
https://ncbi.nlm.nih.gov/pubmed/20418373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.040477
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items