Porcine endogenous retroviruses PERV A and A/C recombinant are insensitive to a range of divergent mammalian TRIM5α proteins including human TRIM5α

The potential risk of cross-species transmission of porcine endogenous retroviruses (PERV) to humans has slowed the development of xenotransplantation, using pigs as organ donors. Here, we show that PERVs are insensitive to restriction by divergent TRIM5α molecules despite the fact that they strongl...

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Main Authors: Wood, Andrew, Webb, Benjamin L. J., Bartosch, Birke, Schaller, Torsten, Takeuchi, Yasuhiro, Towers, Greg J.
格式: Artigo
語言:Inglês
出版: Society for General Microbiology 2009
主題:
Animal
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885064/
https://ncbi.nlm.nih.gov/pubmed/19218217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/vir.0.007377-0
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