Infusion of platelet-derived growth factor or basic fibroblast growth factor induces selective glomerular mesangial cell proliferation and matrix accumulation in rats.

Mesangial cell (MC) proliferation and extracellular matrix expansion are involved in the pathogenesis of glomerulosclerosis and renal failure. In vitro, PDGF and basic fibroblast growth factor (bFGF) regulate MC proliferation and/or matrix production. To elucidate the role of PDGF and bFGF in vivo,...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Floege, J, Eng, E, Young, B A, Alpers, C E, Barrett, T B, Bowen-Pope, D F, Johnson, R J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288499/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7902849/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116918
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