Accumulation of "small dense" low density lipoproteins (LDL) in a homozygous patients with familial defective apolipoprotein B-100 results from heterogenous interaction of LDL subfractions with the LDL receptor.

The interaction of LDL and LDL subfractions from a patient homozygous for familial defective apoB-100 (FDB) has been studied. His LDL cholesterol ranged from 2.65 to 3.34 g/liter. In cultured fibroblasts, binding, internalization, and degradation of the patient's LDL was diminished, but not complete...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	März, W, Baumstark, M W, Scharnagl, H, Ruzicka, V, Buxbaum, S, Herwig, J, Pohl, T, Russ, A, Schaaf, L, Berg, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288496/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8254047/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116915
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