The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

Methotrexate, a folate antagonist, is a potent antiinflammatory agent when used weekly in low concentrations. We examined the hypothesis that the antiphlogistic effects of methotrexate result from its capacity to promote intracellular accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide (AI...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Cronstein, B N, Naime, D, Ostad, E
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1993
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC288465/
https://ncbi.nlm.nih.gov/pubmed/8254024
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk