Glomerulosclerosis induced by in vivo transfection of transforming growth factor-beta or platelet-derived growth factor gene into the rat kidney.

Glomerulosclerosis, a final common lesion of various glomerular diseases, is characterized by mesangial cell proliferation and extracellular matrix (ECM) expansion. TGF-beta and PDGF are known to play a critical role in the regulation of ECM metabolism and mesenchymal cell proliferation, respectivel...

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Pubblicato in:	J Clin Invest
Autori principali:	Isaka, Y, Fujiwara, Y, Ueda, N, Kaneda, Y, Kamada, T, Imai, E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288455/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8254017/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116874
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