Optimized design and data analysis of tag-based cytosine methylation assays

Using the type III restriction-modification enzyme EcoP15I, we isolated sequences flanking sites digested by the methylation-sensitive HpaII enzyme or its methylation-insensitive MspI isoschizomer for massively parallel sequencing. A novel data transformation allows us to normalise HpaII by MspI cou...

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Detalhes bibliográficos
Main Authors: Suzuki, Masako, Jing, Qiang, Lia, Daniel, Pascual, Marién, McLellan, Andrew, Greally, John M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884539/
https://ncbi.nlm.nih.gov/pubmed/20359321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2010-11-4-r36
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