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Genetic Engineering of IgG-Glucuronidase Fusion Proteins

β-Glucuronidase (GUSB) is a lysosomal enzyme that could be developed as a brain therapy for Type VII Mucopolysaccharidosis. However, GUSB does not cross the blood-brain barrier (BBB). To enable BBB transport of the enzyme, human GUSB was re-engineered as a fusion protein with the chimeric monoclonal...

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Bibliografiske detaljer
Main Authors: Boado, Ruben J., Pardridge, William M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884384/
https://ncbi.nlm.nih.gov/pubmed/19827970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10611860903353362
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