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Genetic Engineering of IgG-Glucuronidase Fusion Proteins
β-Glucuronidase (GUSB) is a lysosomal enzyme that could be developed as a brain therapy for Type VII Mucopolysaccharidosis. However, GUSB does not cross the blood-brain barrier (BBB). To enable BBB transport of the enzyme, human GUSB was re-engineered as a fusion protein with the chimeric monoclonal...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2884384/ https://ncbi.nlm.nih.gov/pubmed/19827970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10611860903353362 |
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