Fifth complement cascade protein (C5) cleavage fragments disrupt the SDF-1/CXCR4 axis: Further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells

OBJECTIVE: Having previously demonstrated that the complement system modulates mobilization of hematopoietic stem/progenitor cells (HSPC) in mice, we investigated the involvement of C5 cleavage fragments (C5a/(desArg)C5a) in human HSPC mobilization. METHODS: C5 cleavage fragments in the plasma were...

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Main Authors: Jalili, Ali, Shirvaikar, Neeta, Marquez-Curtis, Leah, Qiu, Yuanyuan, Korol, Chris, Lee, HakMo, Turner, A. Robert, Ratajczak, Mariusz Z., Janowska-Wieczorek, Anna
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884222/
https://ncbi.nlm.nih.gov/pubmed/20153802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2010.02.002
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