Effects of interleukin-1 on syntheses of alkaline phosphatase, type X collagen, and 1,25-dihydroxyvitamin D3 receptor, and matrix calcification in rabbit chondrocyte cultures.

The effect of IL-1 on expression of the mineralization-related phenotype by chondrocytes was examined. In cultures of rabbit growth plate chondrocytes, IL-1 beta at 0.1 ng/ml caused 95% decreases in alkaline phosphatase activity, alkaline phosphatase mRNA levels, the incorporation of 45Ca into insol...

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Bibliographic Details
Main Authors: Kato, Y, Nakashima, K, Iwamoto, M, Murakami, H, Hiranuma, H, Koike, T, Suzuki, F, Fuchihata, H, Ikehara, Y, Noshiro, M
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC288413/
https://ncbi.nlm.nih.gov/pubmed/8227347
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