Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients.

We examined pancreas biopsy specimens from 18 newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients to elucidate the mechanism underlying beta cell destruction. Pancreas islets were seen in all patients and insulitis in eight patients. Infiltrating mononuclear cells consisted of CD4+T,...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Itoh, N, Hanafusa, T, Miyazaki, A, Miyagawa, J, Yamagata, K, Yamamoto, K, Waguri, M, Imagawa, A, Tamura, S, Inada, M
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1993
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288412/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8227346/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116835
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