Phase I Trial of Weekly Tigatuzumab, an Agonistic Humanized Monoclonal Antibody Targeting Death Receptor 5 (DR5)

BACKGROUND: TRA-8 is a murine agonist monoclonal antibody to death receptor 5 (DR5), which is able to trigger apoptosis in DR5 positive human tumor cells without the aid of crosslinking. It has demonstrated cytotoxicity in vitro and in vivo antitumor efficacy to a wide range of solid tumors in murin...

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Detalhes bibliográficos
Main Authors: Forero-Torres, Andres, Shah, Jatin, Wood, Tina, Posey, James, Carlisle, Ronda, Copigneaux, Catherine, Luo, Feng (Roger), Wojtowicz-Praga, Slawomir, Percent, Ivor, Saleh, Mansoor
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883819/
https://ncbi.nlm.nih.gov/pubmed/20187792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cbr.2009.0673
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