Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.

Insulin rapidly stimulates tyrosine kinase activity of its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which in turn associates with phosphatidylinositol 3-kinase (PI 3-kinase), thus activating the enzyme. Glucocorticoid treatment is known...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Saad, M J, Folli, F, Kahn, J A, Kahn, C R
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1993
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288376/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7691892/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116803
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