Systemic bioavailability of hydrofluoroalkane (HFA) formulations of fluticasone/salmeterol in healthy volunteers via pMDI alone and spacer

AIM: To compare a test version of HFA fluticasone/salmeterol (FP/SM) combination inhaler (Neolab, UK) with the reference product Seretide (GlaxoSmithKline, UK). METHODS: An in vitro Anderson cascade impactor was used to compare the fine particle dose (<4.7 µm). Two separate randomized cross-over...

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Autors principals: Clearie, Karine L, Williamson, Peter A, Vaidyanathan, Sriram, Du Bois, Jeannine, Nell, Haylene, Lipworth, Brian J
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2010
Matèries:
Pharmacokinetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883756/
https://ncbi.nlm.nih.gov/pubmed/20565455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2010.03655.x
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