Interaction of human beta 1 thyroid hormone receptor and its mutants with DNA and retinoid X receptor beta. T3 response element-dependent dominant negative potency.

Mutations in the human beta thyroid hormone receptor (h-TR beta) gene are associated with the syndrome of generalized resistance to thyroid hormone. We investigated the interaction of three h-TR beta 1 mutants representing different types of functional impairment (kindreds ED, OK, and PV) with diffe...

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Publicat a:J Clin Invest
Autors principals: Meier, C A, Parkison, C, Chen, A, Ashizawa, K, Meier-Heusler, S C, Muchmore, P, Cheng, S Y, Weintraub, B D
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1993
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288366/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8408652/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116793
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