Attenuated and Lethal Variants of Pichindé Virus Induce Differential Patterns of NF-κB Activation Suggesting a Potential Target for Novel Therapeutics

Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-κB (NF-κB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-κB inhibition as involving increased levels of repressive p50/p50 homod...

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Detalhes bibliográficos
Main Authors: Bowick, Gavin C., Fennewald, Susan M., Zhang, Lihong, Yang, Xianbin, Aronson, Judith F., Shope, Robert E., Luxon, Bruce A., Gorenstein, David G., Herzog, Norbert K.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2009
Assuntos:
Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883487/
https://ncbi.nlm.nih.gov/pubmed/19951183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/vim.2009.0034
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