Lack of relationship between TIMP-1 tumour cell immunoreactivity, treatment efficacy and prognosis in patients with advanced epithelial ovarian cancer

BACKGROUND: Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a natural inhibitor of the matrix metalloproteinases (MMPs) which are proteolytic enzymes involved in degradation of extracellular matrix thereby favoring tumour cell invasion and metastasis. TIMP-1 activity in tumour tissue may therefo...

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Bibliografiske detaljer
Main Authors: Steffensen, Karina Dahl, Waldstrøm, Marianne, Christensen, Rikke Kølby, Bartels, Annette, Brünner, Nils, Jakobsen, Anders
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882920/
https://ncbi.nlm.nih.gov/pubmed/20459644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-185
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