Aminoguanidine treatment increases elasticity and decreases fluid filtration of large arteries from diabetic rats.

The accumulation of advanced glycosylation end-products (AGEs) on collagen and the subsequent stiffening of this matrix protein in diabetes has been described many years ago. Structural modification of collagen in the arterial wall might have important effects on arterial elasticity. Aminoguanidine...

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Udgivet i:J Clin Invest
Main Authors: Huijberts, M S, Wolffenbuttel, B H, Boudier, H A, Crijns, F R, Kruseman, A C, Poitevin, P, Lévy, B I
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC288284/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8376593/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116716
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