Activation of Interferon Response Through Toll-Like Receptor 3 Impacts Viral Pathogenesis and Pulmonary Toll-Like Receptor Expression During Respiratory Syncytial Virus and Influenza Infections in the Cotton Rat Sigmodon hispidus Model

Interferon (IFN) therapy in humans often causes flu-like symptoms by an unknown mechanism. Poly ICLC is a synthetic dsRNA and a Toll-like receptor 3 (TLR3) agonist with a strong IFN-inducing ability. In this work, we analyzed the effect of poly ICLC on pulmonary responses to influenza and respirator...

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Detalhes bibliográficos
Main Authors: Boukhvalova, Marina S., Sotomayor, Talia B., Point, Ryan C., Pletneva, Lioubov M., Prince, Gregory A., Blanco, Jorge C.G.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. publishers 2010
Assuntos:
Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882628/
https://ncbi.nlm.nih.gov/pubmed/20038196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2009.0025
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