Hypoxia inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

Ischemia exists in many diseased tissues including arthritic joints, atherosclerotic plaques and malignant tumors. Macrophages accumulate in these sites and upregulate hypoxia-inducible transcription factors (HIFs) 1 and 2 in response to the hypoxia present. Here we show that the gene expression pro...

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Detalhes bibliográficos
Main Authors: Fang, Hsin-Yu, Hughes, Russell, Murdoch, Craig, Coffelt, Seth, Biswas, Subhra K., Harris, Adrian L., Johnson, Randall S., Imityaz, Hongxia Z., Simon, M. Celeste, Fredlund, Erik, Greten, Florian, Rius, Jordi, Lewis, Claire E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882173/
https://ncbi.nlm.nih.gov/pubmed/19454749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-195941
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