ERβ Impedes Prostate Cancer EMT by Destabilizing HIF-1α and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading

High Gleason grade prostate carcinomas are aggressive, poorly differentiated tumors that exhibit diminished estrogen receptor β (ERβ) expression. We report that a key function of ERβ and its specific ligand 5α-androstane-3β,17β-diol (3β-adiol) is to maintain an epithelial phenotype and repress mesen...

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Detalhes bibliográficos
Main Authors: Mak, Paul, Leav, Irwin, Pursell, Bryan, Bae, Donggoo, Yang, Xiaofang, Taglienti, Cherie A., Gouvin, Lindsey M., Sharma, Vishva M., Mercurio, Arthur M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881822/
https://ncbi.nlm.nih.gov/pubmed/20385358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.02.030
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