Calnexin Deficiency Leads to Dysmyelination

Calnexin is a molecular chaperone and a component of the quality control of the secretory pathway. We have generated calnexin gene-deficient mice (cnx(−/−)) and showed that calnexin deficiency leads to myelinopathy. Calnexin-deficient mice were viable with no discernible effects on other systems, in...

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Detalhes bibliográficos
Main Authors: Kraus, Allison, Groenendyk, Jody, Bedard, Karen, Baldwin, Troy A., Krause, Karl-Heinz, Dubois-Dauphin, Michel, Dyck, Jason, Rosenbaum, Erica E., Korngut, Lawrence, Colley, Nansi J., Gosgnach, Simon, Zochodne, Douglas, Todd, Kathryn, Agellon, Luis B., Michalak, Marek
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881815/
https://ncbi.nlm.nih.gov/pubmed/20400506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.107201
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