Allosteric Drug Discrimination Is Coupled to Mechanochemical Changes in the Kinesin-5 Motor Core

Essential in mitosis, the human Kinesin-5 protein is a target for >80 classes of allosteric compounds that bind to a surface-exposed site formed by the L5 loop. Not established is why there are differing efficacies in drug inhibition. Here we compare the ligand-bound states of two L5-directed inh...

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Autors principals: Kim, Elizabeth D., Buckley, Rebecca, Learman, Sarah, Richard, Jessica, Parke, Courtney, Worthylake, David K., Wojcik, Edward J., Walker, Richard A., Kim, Sunyoung
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881790/
https://ncbi.nlm.nih.gov/pubmed/20299460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.092072
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