Sphingosine Kinase Mediates Resistance to the Synthetic Retinoid N-(4-Hydroxyphenyl)retinamide in Human Ovarian Cancer Cells

A2780 human ovarian carcinoma cells respond to treatment with the synthetic retinoid N-(4-hydroxyphenyl)retinamide (HPR) with the production of dihydroceramide and with a concomitant reduction of cell proliferation and induction of apoptosis. The derived HPR-resistant clonal cell line, A2780/HPR, is...

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Autori principali: Illuzzi, Giuditta, Bernacchioni, Caterina, Aureli, Massimo, Prioni, Simona, Frera, Gianluca, Donati, Chiara, Valsecchi, Manuela, Chigorno, Vanna, Bruni, Paola, Sonnino, Sandro, Prinetti, Alessandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Lipids
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881785/
https://ncbi.nlm.nih.gov/pubmed/20404323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072801
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